If You're Not Sticking To A Regular Sleep Schedule, You're Hurting Your Health, Study Says
Ok, I admit it. I often stay up late on weekends, catching up on TV or seeing friends, then decadently allow myself to slumber for hours past my regular wake-up time the next morning.
To a diehard night owl like me, this is delicious freedom, a sort of personal protest against the rigidity of the obnoxious workday alarm.
Sound familiar? If so, fellow snooze buddies, it turns out our lack of a regular sleep routine is hurting our health.
A new study published Monday found changing your regular sleep-wake time by 90 minutes -- in either direction -- significantly increases your chance of having a heart attack or heart disease.
A regular sleep time was defined in the study as less than 30 minutes difference, on average, across seven nights.
That suggests, Huang said, that high day-to-day variability in sleep duration or timing may be a "novel and independent cardiovascular risk factor."
Messing with our internal sleep clock "has been linked to cardiovascular risk factors like hypertension, insulin resistance or diabetes," Huang said, "but this is the first study to link an irregular sleep pattern pattern with cardiovascular disease."
The study followed more than 2,000 people ages 45 to 84 without any cardiovascular disease over a five-year period. After a baseline exam, follow-up physicals measured any lifestyle, medication or disease changes, while a sleep study tested for sleep disorders like apnea.
Then the participants wore a sleep wrist tracker for seven consecutive nights.
While it may appear this link is strongest for the elderly, that may not be the case. A previous analysis of 53 studies on people age 18 and up found younger age to be more consistently associated with a variable sleep cycle.
Get moving. Exercise is key to promoting good sleep. As little as 10 minutes a day of walking, biking or other aerobic exercise can "drastically improve nighttime sleep quality," according to the National Sleep Foundation.
Strive for cooler temperatures. Make sure your bed and pillows are comfortable, and the room is cool: Between 60 and 67 degrees is best. Don't watch TV or work in your bedroom. You want your brain to think of the room as only for sleep.
Avoid certain food and drink. Avoid stimulants such as nicotine or coffee after mid afternoon, especially if you have insomnia. Alcohol is another no-no. You may think it helps you doze off, but you are more likely to wake in the night as your body begins to process the spirits.
Develop a routine. Taking a warm bath or shower, reading a book, listening to soothing music, meditating or doing light stretches are all good options.
Be good to your circadian rhythm. "Like your mom always told you, you should have a regular bedtime and a regular time for getting up in the morning," advised Goff.
Keep yourself in the dark. Be sure to eliminate all bright lights, as even the blue light of cellphones or laptops can be disruptive. If that's hard to accomplish, think about using eye shades and blackout curtains to keep the room dark. But during the day, try to get good exposure to natural light, as that will help regulate your circadian rhythm.
Follow these steps, and you'll be well on your way to improving your sleep habits and your health.
Researchers at the University of Toronto have found a potential explanation of what disrupted sleep does to the human brain. They studied 685 adults older than 65, who participated in two large U.S. studies, and looked at their sleep patterns, their performance on thinking tests and, later, their brain-tissue samples after the participants died.
The researchers’ findings, published Wednesday in the journal Science Advances, indicate disrupted sleep may contribute to changes in a type of immune cell in the brain called microglia, which in turn appear to be related to poorer cognitive functions, such as memory and the ability to reason.
While further research is needed to determine whether fixing people’s sleep problems can prevent or reverse cognitive decline, Andrew Lim, one of the authors of the study, said fragmented sleep should not be ignored.
In the study, researchers recorded participants’ sleep disruptions by having them wear wristwatch-like actigraphy devices, which could detect subtle signs of them awakening at night, even when participants themselves were unaware. The participants were asked to wear these devices for 10 days, once a year, for a median period of two years.
Participants also performed a series of cognitive tests annually. They agreed to donate their brains for research after their death, and researchers were able to examine their microglia in two ways. First, since activated and resting microglia differ in appearance, researchers were able to determine the density and proportion of activated microglia by looking at participants’ brain tissue under a microscope, Dr. Lim said. Then, they examined patterns of gene expression to identify “older” versus “younger” microglia – that is, whether the microglia appeared as though they came from an older person from a genetic perspective.
The researchers found connections between all three variables. Individuals who had higher levels of sleep fragmentation had a higher proportion of activated microglia and gene expression characteristic of older microglia. This was the case both for participants who had Alzheimer’s disease and those who did not. Those with poorer sleep also performed worse on their cognitive tests. And participants who had a greater proportion of activated microglia or genetically older microglia also had poorer cognitive test results.
Professor Teresa Liu-Ambrose of the University of British Columbia, who was not involved in the study, said the findings align with what researchers know thus far about the importance of sleep and the possible contribution of poor sleep to Alzheimer’s disease.
Dr. Liu-Ambrose, the Canada research chair in physical activity, mobility and cognitive neuroscience at UBC, said good-quality sleep is believed to allow the brain to clear itself of toxic beta-amyloid protein, the buildup of which is one of the characteristics of Alzheimer’s disease. And, she said, there is also good evidence to suggest an accumulation of beta-amyloid can further contribute to disrupted sleep.
To a diehard night owl like me, this is delicious freedom, a sort of personal protest against the rigidity of the obnoxious workday alarm.
Sound familiar? If so, fellow snooze buddies, it turns out our lack of a regular sleep routine is hurting our health.
A new study published Monday found changing your regular sleep-wake time by 90 minutes -- in either direction -- significantly increases your chance of having a heart attack or heart disease.
A regular sleep time was defined in the study as less than 30 minutes difference, on average, across seven nights.
"Compared with people who had the most regular sleep time, those with the most irregular sleep time -- more than a 90 minute difference on average across seven nights -- had more than a two-fold increased risk of cardiovascular disease over a 5-year period," said study author Tianyi Huang, an assistant professor of medicine at Harvard Medical School.The link remained strong even after controlling for cholesterol, blood pressure and other known cardiovascular risk factors, as well as sleep issues such as insomnia, sleep apnea and sleep duration.
That suggests, Huang said, that high day-to-day variability in sleep duration or timing may be a "novel and independent cardiovascular risk factor."
"That's huge," said Dr. David Goff, who directs the division of cardiovascular sciences at the United States National Heart, Lung and Blood Institute.
"One out of three people in the US die from heart disease, and 60% of us will have a major cardiovascular disease event before we die," said Goff, who was not involved in the study.
"People are living busy, stressful lives and not getting a lot of sleep during the week," Goff said. "Then they are trying to get catchup sleep on the weekend, and that's not a healthy pattern."
The link between sleep and heart
The cardiovascular system -- including heart rate, blood pressure and vascular tone -- operates on a strong circadian rhythm to maintain normal functioning.Messing with our internal sleep clock "has been linked to cardiovascular risk factors like hypertension, insulin resistance or diabetes," Huang said, "but this is the first study to link an irregular sleep pattern pattern with cardiovascular disease."
The study followed more than 2,000 people ages 45 to 84 without any cardiovascular disease over a five-year period. After a baseline exam, follow-up physicals measured any lifestyle, medication or disease changes, while a sleep study tested for sleep disorders like apnea.
Then the participants wore a sleep wrist tracker for seven consecutive nights.
"About a quarter of people in this age range didn't have a regular time for going to sleep," Goff said.Since many of the participants were retired, it was surprising to find some 500 people had significantly disrupted sleep schedules.
While it may appear this link is strongest for the elderly, that may not be the case. A previous analysis of 53 studies on people age 18 and up found younger age to be more consistently associated with a variable sleep cycle.
"This sleep irregularity may be even more common among younger people," Huang said. "Younger people may have more demands from study and from work, and those may also influence whether they can have a regular sleep pattern or not."If that becomes a habit in life, the results could be dangerous. That's because the study also found a linear upward link between disrupted sleep cycles and heart issues.
"The more you sleep irregularly, the higher the risk you have," Huang said.
Better sleep habits
The good news is that you can do something about your poor sleep habits.Get moving. Exercise is key to promoting good sleep. As little as 10 minutes a day of walking, biking or other aerobic exercise can "drastically improve nighttime sleep quality," according to the National Sleep Foundation.
Strive for cooler temperatures. Make sure your bed and pillows are comfortable, and the room is cool: Between 60 and 67 degrees is best. Don't watch TV or work in your bedroom. You want your brain to think of the room as only for sleep.
Avoid certain food and drink. Avoid stimulants such as nicotine or coffee after mid afternoon, especially if you have insomnia. Alcohol is another no-no. You may think it helps you doze off, but you are more likely to wake in the night as your body begins to process the spirits.
Develop a routine. Taking a warm bath or shower, reading a book, listening to soothing music, meditating or doing light stretches are all good options.
Be good to your circadian rhythm. "Like your mom always told you, you should have a regular bedtime and a regular time for getting up in the morning," advised Goff.
Keep yourself in the dark. Be sure to eliminate all bright lights, as even the blue light of cellphones or laptops can be disruptive. If that's hard to accomplish, think about using eye shades and blackout curtains to keep the room dark. But during the day, try to get good exposure to natural light, as that will help regulate your circadian rhythm.
Follow these steps, and you'll be well on your way to improving your sleep habits and your health.
By Sandee LaMotte, CNN March 2, 2020
source: www.cnn.com
Study Finds Link Between Dementia And Lack Of Sleep
A growing body of research suggests poor sleep is tied to impaired thinking and dementia in older adults. Now a new study may shed light on why.Researchers at the University of Toronto have found a potential explanation of what disrupted sleep does to the human brain. They studied 685 adults older than 65, who participated in two large U.S. studies, and looked at their sleep patterns, their performance on thinking tests and, later, their brain-tissue samples after the participants died.
The researchers’ findings, published Wednesday in the journal Science Advances, indicate disrupted sleep may contribute to changes in a type of immune cell in the brain called microglia, which in turn appear to be related to poorer cognitive functions, such as memory and the ability to reason.
While further research is needed to determine whether fixing people’s sleep problems can prevent or reverse cognitive decline, Andrew Lim, one of the authors of the study, said fragmented sleep should not be ignored.
Many people believe “having bad sleep is just part of aging, and it’s something that’s annoying but to be tolerated, rather than aggressively managed or aggressively investigated,” said Dr. Lim, an associate professor of neurology at the University of Toronto and sleep neurologist at the Sunnybrook Health Sciences Centre. “This adds one more reason to take sleep [problems] seriously and to look for your treatable causes and to address them.”This study builds on previous research, including studies on rodents and genetic studies, that suggest microglia play a role in the link between poor sleep and cognitive impairment and dementia. Microglia normally help fight infections and clear debris from the brain. But dysfunction of microglia appears to be involved in the development of Alzheimer’s disease, Dr. Lim said.
In the study, researchers recorded participants’ sleep disruptions by having them wear wristwatch-like actigraphy devices, which could detect subtle signs of them awakening at night, even when participants themselves were unaware. The participants were asked to wear these devices for 10 days, once a year, for a median period of two years.
Participants also performed a series of cognitive tests annually. They agreed to donate their brains for research after their death, and researchers were able to examine their microglia in two ways. First, since activated and resting microglia differ in appearance, researchers were able to determine the density and proportion of activated microglia by looking at participants’ brain tissue under a microscope, Dr. Lim said. Then, they examined patterns of gene expression to identify “older” versus “younger” microglia – that is, whether the microglia appeared as though they came from an older person from a genetic perspective.
The researchers found connections between all three variables. Individuals who had higher levels of sleep fragmentation had a higher proportion of activated microglia and gene expression characteristic of older microglia. This was the case both for participants who had Alzheimer’s disease and those who did not. Those with poorer sleep also performed worse on their cognitive tests. And participants who had a greater proportion of activated microglia or genetically older microglia also had poorer cognitive test results.
Professor Teresa Liu-Ambrose of the University of British Columbia, who was not involved in the study, said the findings align with what researchers know thus far about the importance of sleep and the possible contribution of poor sleep to Alzheimer’s disease.
Dr. Liu-Ambrose, the Canada research chair in physical activity, mobility and cognitive neuroscience at UBC, said good-quality sleep is believed to allow the brain to clear itself of toxic beta-amyloid protein, the buildup of which is one of the characteristics of Alzheimer’s disease. And, she said, there is also good evidence to suggest an accumulation of beta-amyloid can further contribute to disrupted sleep.
“It’s a vicious cycle,” she said.
“What [the new study] really does show is that it’s important to protect your sleep overall," she said. "[Sleep quality] does seem to have very direct effects on the brain, both acutely, but also chronically.”
WENCY LEUNG HEALTH REPORTER DECEMBER 11, 2019
FOLLOW WENCY LEUNG ON TWITTER @WENCYLEUNG
source: www.theglobeandmail.com
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